miRNAs are conserved 21−22-nucleotide (nt) noncoding RNAs that downregulate gene expression post-transcriptionally (reviewed in ref. 1). In the nucleus, Drosha processes long primary miRNA (pri-miRNA) ...

A 45-nucleotide strand of RNA can now synthesize both its mirror-image complement and a copy of itself, bringing scientists ...

We the authors are retracting this Article because our efforts to repeat and follow up on the results have been unsuccessful. Specifically, we have been unable to reproduce observations suggesting ...

Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may ...

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a ...

Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...

Having an intricate understanding of gene regulation is the underlying key of molecular and cell biology. For many years we have been taught that DNA is double-stranded and RNA is single-stranded, but ...

In this free webinar, learn how innovative long RNA manufacturing approaches can drive the development of next-generation RNA medicines. Attendees will understand the limitations of current methods ...

A team of scientists from Russia studied the role of double-stranded fragments of the maturing RNA and showed that the interaction between distant parts of the RNA can regulate gene expression. The ...

Researchers in China have developed a new method that allows them to insert long stretches of DNA into a genome. The process, named GRAND editing, is one of a handful of new systems aimed at using two ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...