Figure 1: Cartoon structures of the I·C and I·A base pairs. The increased width of the purine-purine I·A base pair requires the geometry of the anticodon to change, as the codon base is held in place ...
One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a ...
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